Ontology highlight
ABSTRACT:
SUBMITTER: Spillman MA
PROVIDER: S-EPMC3804411 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Spillman Monique A MA Manning Nicole G NG Dye Wendy W WW Sartorius Carol A CA Post Miriam D MD Harrell Joshua Chuck JC Jacobsen Britta M BM Horwitz Kathryn B KB
Cancer research 20101019 21
Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed preexisting disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperitoneal mouse xenograft model using ZsGreen fluorescent ER(-) 2008 and ER(+) PEO4 human EOC cells. Tumor growth was quantified by in vivo fluorescent imaging. In ER(+) tumors, E2 significantly increased s ...[more]