Ontology highlight
ABSTRACT:
SUBMITTER: Khatri P
PROVIDER: S-EPMC3804941 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Khatri Purvesh P Roedder Silke S Kimura Naoyuki N De Vusser Katrien K Morgan Alexander A AA Gong Yongquan Y Fischbein Michael P MP Robbins Robert C RC Naesens Maarten M Butte Atul J AJ Sarwal Minnie M MM
The Journal of experimental medicine 20131014 11
Using meta-analysis of eight independent transplant datasets (236 graft biopsy samples) from four organs, we identified a common rejection module (CRM) consisting of 11 genes that were significantly overexpressed in acute rejection (AR) across all transplanted organs. The CRM genes could diagnose AR with high specificity and sensitivity in three additional independent cohorts (794 samples). In another two independent cohorts (151 renal transplant biopsies), the CRM genes correlated with the exte ...[more]