Ontology highlight
ABSTRACT:
SUBMITTER: Ge Y
PROVIDER: S-EPMC3804943 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ge Yan Y Jiang Chao C Sung Sun-Sang J SS Bagavant Harini H Dai Chao C Wang Hongyang H Kannapell Carol C CC Cathro Helen P HP Gaskin Felicia F Fu Shu Man SM
The Journal of experimental medicine 20131007 11
Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with chronic glomerulonephritis (cGN) and acute GN (aGN). NZM2328.Lc1R27 (R27) was generated by introgressing a C57L/J region where Cgnz1 is located to NZM2328. R27 female mice developed aGN mediated by immune complex (IC) deposition and complement activation without progression to cGN with severe proteinuria. End stage renal disease (ESRD) was not seen in R27 mice as old as 15 mo. Thus, aGN and cGN are under separate gene ...[more]