Ontology highlight
ABSTRACT:
SUBMITTER: Fabbri G
PROVIDER: S-EPMC3804949 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Fabbri Giulia G Khiabanian Hossein H Holmes Antony B AB Wang Jiguang J Messina Monica M Mullighan Charles G CG Pasqualucci Laura L Rabadan Raul R Dalla-Favera Riccardo R
The Journal of experimental medicine 20131014 11
Richter syndrome (RS) derives from the rare transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly of the diffuse large B cell lymphoma (DLBCL) type. The molecular pathogenesis of RS is only partially understood. By combining whole-exome sequencing and copy-number analysis of 9 CLL-RS pairs and of an extended panel of 43 RS cases, we show that this aggressive disease typically arises from the predominant CLL clone by acquiring an average of ∼20 genetic le ...[more]