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Impact of c-MYC protein expression on outcome of patients with early-stage HER2+ breast cancer treated with adjuvant trastuzumab NCCTG (alliance) N9831.


ABSTRACT: This study investigated the association between tumor MYC protein expression and disease-free survival (DFS) of patients randomized to receive chemotherapy alone (Arm A) or chemotherapy with sequential (Arm B) or concurrent trastuzumab (Arm C) in the N9831 (Alliance) adjuvant HER2(+) trastuzumab breast cancer trial.This analysis included 1,736 patients randomized to Arms A, B, and C on N9831. Nuclear MYC protein expression was determined in tissue microarray sections containing three biopsies per patient or whole tissue sections using standard immunohistochemistry (clone 9E10). A tumor was considered positive for MYC protein overexpression (MYC(+)) if the nuclear 3+ staining percentage was more than 30%.Five hundred and seventy-four (33%) tumors were MYC(+). MYC(+) was associated with hormone receptor positivity (?(2), P = 0.006), tumors 2 cm or more (?(2), P = 0.02), and a higher rate of nodal positivity (?(2), P < 0.001). HRs for DFS (median follow-up: 6.1 years) for Arm C versus A were 0.52 (P = 0.006) and 0.65 (P = 0.006) for patients with MYC(+) and MYC(-) tumors, respectively (P(interaction) = 0.40). For Arm B versus A, HRs for patients with MYC(+) and MYC(-) tumors were 0.79 (P = 0.21) and 0.74 (P = 0.04), respectively (P(interaction) = 0.71). For Arm C versus B, HRs for patients with MYC(+) and MYC(-) tumors were 0.56 (P = 0.02) and 0.89 (P = 0.49), respectively (P(interaction) = 0.17).Our data do not support an impact of tumor MYC protein expression on differential benefit from adjuvant trastuzumab.

SUBMITTER: Dueck AC 

PROVIDER: S-EPMC3805021 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Impact of c-MYC protein expression on outcome of patients with early-stage HER2+ breast cancer treated with adjuvant trastuzumab NCCTG (alliance) N9831.

Dueck Amylou C AC   Reinholz Monica M MM   Geiger Xochiquetzal J XJ   Tenner Kathleen K   Ballman Karla K   Jenkins Robert B RB   Riehle Darren D   Chen Beiyun B   McCullough Ann E AE   Davidson Nancy E NE   Martino Silvana S   Sledge George W GW   Kaufman Peter A PA   Kutteh Leila A LA   Gralow Julie J   Harris Lyndsay N LN   Ingle James N JN   Lingle Wilma L WL   Perez Edith A EA  

Clinical cancer research : an official journal of the American Association for Cancer Research 20130821 20


<h4>Purpose</h4>This study investigated the association between tumor MYC protein expression and disease-free survival (DFS) of patients randomized to receive chemotherapy alone (Arm A) or chemotherapy with sequential (Arm B) or concurrent trastuzumab (Arm C) in the N9831 (Alliance) adjuvant HER2(+) trastuzumab breast cancer trial.<h4>Experimental design</h4>This analysis included 1,736 patients randomized to Arms A, B, and C on N9831. Nuclear MYC protein expression was determined in tissue micr  ...[more]

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