Unknown

Dataset Information

0

Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.


ABSTRACT: Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Our analysis revealed highly dynamic and cell-specific expression patterns for lincRNAs during T cell differentiation. These lincRNAs were located in genomic regions enriched for genes that encode proteins with immunoregulatory functions. Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6. We found that the lincRNA LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the TH2 subset of helper T cells and was important for the migration of TH2 cells.

SUBMITTER: Hu G 

PROVIDER: S-EPMC3805781 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.

Hu Gangqing G   Tang Qingsong Q   Sharma Suveena S   Yu Fang F   Escobar Thelma M TM   Muljo Stefan A SA   Zhu Jinfang J   Zhao Keji K  

Nature immunology 20130922 11


Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Our analysis revealed highly dynamic and cell-specific expression patterns for lincRNAs during T cell differentiation. These lincRNAs were located in genomic regions enriched for  ...[more]

Similar Datasets

| S-EPMC4410435 | biostudies-literature
| S-EPMC8170422 | biostudies-literature
| S-EPMC4943187 | biostudies-literature
| S-EPMC3552696 | biostudies-literature
| S-EPMC5656573 | biostudies-literature
| S-EPMC4578992 | biostudies-literature
| S-EPMC9242727 | biostudies-literature
| S-EPMC7886007 | biostudies-literature
| S-EPMC4264600 | biostudies-literature
| S-EPMC4702595 | biostudies-literature