Ontology highlight
ABSTRACT:
SUBMITTER: Sourisseau M
PROVIDER: S-EPMC3805793 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Sourisseau Marion M Goldman Orit O He Wenqian W Gori Jennifer L JL Kiem Hans-Peter HP Gouon-Evans Valerie V Evans Matthew J MJ
Gastroenterology 20130725 5
The narrow species tropism of hepatitis C virus (HCV) limits animal studies. We found that pigtail macaque (Macaca nemestrina) hepatic cells derived from induced pluripotent stem cells support the entire HCV life cycle, although infection efficiency was limited by defects in the HCV cell entry process. This block was overcome by either increasing occludin expression, complementing the cells with human CD81, or infecting them with a strain of HCV with less restricted requirements for CD81. Using ...[more]