Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC3806129 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wang Kui K Gao Jianzhao J Shen Shiyi S Tuszynski Jack A JA Ruan Jishou J Hu Gang G
BioMed research international 20130930
Since proteins carry out their functions through interactions with other molecules, accurately identifying the protein-ligand binding site plays an important role in protein functional annotation and rational drug discovery. In the past two decades, a lot of algorithms were present to predict the protein-ligand binding site. In this paper, we introduce statistical depth function to define negative samples and propose an SVM-based method which integrates sequence and structural information to pre ...[more]