STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury.
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ABSTRACT:
SUBMITTER: Lang C
PROVIDER: S-EPMC3807223 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
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STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury.
Lang Claudia C Bradley Peter M PM Jacobi Anne A Kerschensteiner Martin M Bareyre Florence M FM
EMBO reports 20130809 10
If and how neurons remodel their connections after CNS injury critically influences recovery of function. Here, we investigate the role of the growth-initiating transcription factor STAT3 during remodelling of the injured corticospinal tract (CST). Endogenous STAT3 expression in lesioned cortical projection neurons is transient but can be sustained by viral gene transfer. Sustained activation of STAT3 enhances remodelling of lesioned CST fibres and induces de novo formation of collaterals from u ...[more]
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