Ontology highlight
ABSTRACT:
SUBMITTER: Korendovych IV
PROVIDER: S-EPMC3807245 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Korendovych Ivan V IV Kim Yong Ho YH Ryan Andrew H AH Lear James D JD Degrado William F WF Shandler Scott J SJ
Organic letters 20101014 22
The first computationally designed self-assembling oligomer consisting of exclusively β-amino acids (βAAs) is presented. The packing of a β-3(14) helix into coiled-coils of varying stoichiometries as a function of amino acid sequence is examined. β-Peptides with hVal repeating every third residue in the sequence appeared to have a strong propensity to pack into hexameric bundles. The designed sequence was synthesized and characterized with CD spectroscopy, NMR, and analytical ultracentrifugation ...[more]