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Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.


ABSTRACT: Expression of cell-intrinsic antiviral factors suppresses HIV-1 replication. We hypothesized that cellular activation modulates host restriction and susceptibility to HIV-1 infection. We measured the gene expression of 34 antiviral factors in healthy peripheral blood mononuclear cells (PBMC). Cellular activation induced expression of interferon-stimulated gene 15 (ISG15), tripartite motif 5? (TRIM5?), bone marrow stromal cell antigen 2 (BST-2)/tetherin, and certain apolipoprotein B mRNA editing enzyme 3 (APOBEC3) family members. Expression of RTF1, RNA polymerase II-associated factor 1 (PAF1), TRIM11, TRIM26, and BST-2/tetherin correlated with decreased HIV-1 infectivity. This report demonstrates synchronous effects of activation-induced antiviral genes on HIV-1 infectivity, providing candidates for pharmacological manipulation.

SUBMITTER: Raposo RA 

PROVIDER: S-EPMC3807358 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.

Raposo Rui André Saraiva RA   Abdel-Mohsen Mohamed M   Bilska Miroslawa M   Montefiori David C DC   Nixon Douglas F DF   Pillai Satish K SK  

Journal of virology 20130821 21


Expression of cell-intrinsic antiviral factors suppresses HIV-1 replication. We hypothesized that cellular activation modulates host restriction and susceptibility to HIV-1 infection. We measured the gene expression of 34 antiviral factors in healthy peripheral blood mononuclear cells (PBMC). Cellular activation induced expression of interferon-stimulated gene 15 (ISG15), tripartite motif 5α (TRIM5α), bone marrow stromal cell antigen 2 (BST-2)/tetherin, and certain apolipoprotein B mRNA editing  ...[more]

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