Ontology highlight
ABSTRACT:
SUBMITTER: Molina-Cruz A
PROVIDER: S-EPMC3807741 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Molina-Cruz Alvaro A Garver Lindsey S LS Alabaster Amy A Bangiolo Lois L Haile Ashley A Winikor Jared J Ortega Corrie C van Schaijk Ben C L BC Sauerwein Robert W RW Taylor-Salmon Emma E Barillas-Mury Carolina C
Science (New York, N.Y.) 20130509 6135
Plasmodium falciparum transmission by Anopheles gambiae mosquitoes is remarkably efficient, resulting in a very high prevalence of human malaria infection in sub-Saharan Africa. A combination of genetic mapping, linkage group selection, and functional genomics was used to identify Pfs47 as a P. falciparum gene that allows the parasite to infect A. gambiae without activating the mosquito immune system. Disruption of Pfs47 greatly reduced parasite survival in the mosquito, and this phenotype could ...[more]