Ontology highlight
ABSTRACT:
SUBMITTER: Vidler LR
PROVIDER: S-EPMC3807807 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20131003 20
Bromodomains (BRDs) are epigenetic readers that recognize acetylated-lysine (KAc) on proteins and are implicated in a number of diseases. We describe a virtual screening approach to identify BRD inhibitors. Key elements of this approach are the extensive design and use of substructure queries to compile a set of commercially available compounds featuring novel putative KAc mimetics and docking this set for final compound selection. We describe the validation of this approach by applying it to th ...[more]