Nuclear RNase P of Trypanosoma brucei: a single protein in place of the multicomponent RNA-protein complex.
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ABSTRACT:
SUBMITTER: Taschner A
PROVIDER: S-EPMC3807811 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Nuclear RNase P of Trypanosoma brucei: a single protein in place of the multicomponent RNA-protein complex.
Taschner Andreas A Weber Christoph C Buzet Aurélie A Hartmann Roland K RK Hartig Andreas A Rossmanith Walter W
Cell reports 20120628 1
RNase P is the endonuclease that removes 5' extensions from tRNA precursors. In its best-known form, the enzyme is composed of a catalytic RNA and a protein moiety variable in number and mass. This ribonucleoprotein enzyme is widely considered ubiquitous and apparently reached its highest complexity in the eukaryal nucleus, where it is typically composed of at least ten subunits. Here, we show that in the protist Trypanosoma brucei, two proteins are the sole forms of RNase P. They localize to th ...[more]
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