Ontology highlight
ABSTRACT:
SUBMITTER: Libraty DH
PROVIDER: S-EPMC3808280 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Libraty Daniel H DH Zhang Lei L Woda Marcia M Acosta Luz P LP Obcena Anamae A Brion Job D JD Capeding Rosario Z RZ
PloS one 20131025 10
Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1β and IL-6 in monocytes ...[more]