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Toll-like receptor induced pro-interleukin-1? and interleukin-6 in monocytes are lower in healthy infants compared to adults.

ABSTRACT: Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1?, IL-6, and tumor necrosis factor (TNF)-? between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1? and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-?. Lower TLR-induced production of pro-IL-1? and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.

SUBMITTER: Libraty DH

PROVIDER: S-EPMC3808280 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Toll-like receptor induced pro-interleukin-1β and interleukin-6 in monocytes are lower in healthy infants compared to adults.

Libraty Daniel H DH Zhang Lei L Woda Marcia M Acosta Luz P LP Obcena Anamae A Brion Job D JD Capeding Rosario Z RZ

PloS one 20131025 10

Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1β and IL-6 in monocytes ...[more]

PMID: 24205068

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