Ontology highlight
ABSTRACT:
SUBMITTER: Lin ST
PROVIDER: S-EPMC3808585 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Lin Shu-Ting ST Huang Yong Y Zhang Luoying L Heng Mary Y MY Ptácek Louis J LJ Fu Ying-Hui YH
Proceedings of the National Academy of Sciences of the United States of America 20131007 43
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-2 ...[more]