Ontology highlight
ABSTRACT:
SUBMITTER: Wier AD
PROVIDER: S-EPMC3808610 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Wier Adam D AD Mayekar Manasi K MK Héroux Annie A Arndt Karen M KM VanDemark Andrew P AP
Proceedings of the National Academy of Sciences of the United States of America 20131007 43
Polymerase associated factor 1 complex (Paf1C) broadly influences gene expression by regulating chromatin structure and the recruitment of RNA-processing factors during transcription elongation. The Plus3 domain of the Rtf1 subunit mediates Paf1C recruitment to genes by binding a repeating domain within the elongation factor Spt5 (suppressor of Ty). Here we provide a molecular description of this interaction by reporting the structure of human Rtf1 Plus3 in complex with a phosphorylated Spt5 rep ...[more]