Ontology highlight
ABSTRACT:
SUBMITTER: Hur JH
PROVIDER: S-EPMC3808699 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Aging 20130901 9
A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies. However, the interplay between energy homeostasis, stem cells, and organismal aging remains poorly understood. Here, we report that expression of the single-subunit yeast alternative NADH dehydrogenase, ndi1, in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends lifespan. In addition, ex ...[more]