Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.
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ABSTRACT:
SUBMITTER: Alvarez JV
PROVIDER: S-EPMC3808871 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.
Alvarez James V JV Pan Tien-Chi TC Ruth Jason J Feng Yi Y Zhou Alice A Pant Dhruv D Grimley Joshua S JS Wandless Thomas J TJ Demichele Angela A Chodosh Lewis A LA
Cancer cell 20130613 1
Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is downregulated during tumor recurrence and that Par-4 downregulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor response to neo ...[more]
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