Ontology highlight
ABSTRACT:
SUBMITTER: Benezech C
PROVIDER: S-EPMC3809035 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Bénézech Cécile C Mader Emma E Desanti Guillaume G Khan Mahmood M Nakamura Kyoko K White Andrea A Ware Carl F CF Anderson Graham G Caamaño Jorge H JH
Immunity 20120830 4
Lymph node development during embryogenesis involves lymphotoxin-β receptor engagement and subsequent differentiation of a poorly defined population of mesenchymal cells into lymphoid tissue organizer cells. Here, we showed that embryonic mesenchymal cells with characteristics of adipocyte precursors present in the microenvironment of lymph nodes gave rise to lymph node organizer cells. Signaling through the lymphotoxin-β receptor controlled the fate of adipocyte precursor cells by blocking adip ...[more]