Ontology highlight
ABSTRACT:
SUBMITTER: Klein F
PROVIDER: S-EPMC3809838 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Klein Florian F Halper-Stromberg Ariel A Horwitz Joshua A JA Gruell Henning H Scheid Johannes F JF Bournazos Stylianos S Mouquet Hugo H Spatz Linda A LA Diskin Ron R Abadir Alexander A Zang Trinity T Dorner Marcus M Dorner Marcus M Billerbeck Eva E Labitt Rachael N RN Gaebler Christian C Marcovecchio Paola P Incesu Reha-Baris RB Eisenreich Thomas R TR Bieniasz Paul D PD Seaman Michael S MS Bjorkman Pamela J PJ Ravetch Jeffrey V JV Ploss Alexander A Nussenzweig Michel C MC
Nature 20121024 7427
Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection. Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time. However, these experiments were performed before the recent discovery of more potent anti-HIV-1 antibodies and their improvement by structure-based design. Here we re-examine passive antibody transfer a ...[more]