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The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.

ABSTRACT: Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection.

SUBMITTER: Kim MV

PROVIDER: S-EPMC3809840 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.

Kim Myoungjoo V MV Ouyang Weiming W Liao Will W Zhang Michael Q MQ Li Ming O MO

Immunity 20130808 2

Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation se ...[more]

PMID: 23932570

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