Ontology highlight
ABSTRACT:
SUBMITTER: Dreveny I
PROVIDER: S-EPMC380986 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Dreveny Ingrid I Kondo Hisao H Uchiyama Keiji K Shaw Anthony A Zhang Xiaodong X Freemont Paul S PS
The EMBO journal 20040226 5
The AAA ATPase p97/VCP is involved in many cellular events including ubiquitin-dependent processes and membrane fusion. In the latter, the p97 adaptor protein p47 is of central importance. In order to provide insight into the molecular basis of p97 adaptor binding, we have determined the crystal structure of p97 ND1 domains complexed with p47 C-terminal domain at 2.9 A resolution. The structure reveals that the p47 ubiquitin regulatory X domain (UBX) domain interacts with the p97 N domain via a ...[more]