Ontology highlight
ABSTRACT:
SUBMITTER: Sun C
PROVIDER: S-EPMC3810165 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Sun Chongxiu C Alkhoury Kenan K Wang Ying I YI Foster Greg A GA Radecke Christopher E CE Tam Kayan K Edwards Christina M CM Facciotti Marc T MT Armstrong Ehrin J EJ Knowlton Anne A AA Newman John W JW Passerini Anthony G AG Simon Scott I SI
Circulation research 20120808 8
<h4>Rationale</h4>A high-fat diet accompanied by hypertriglyceridemia increases an individual's risk for development of atherosclerosis. An early event in this process is monocyte recruitment through binding to vascular cell adhesion molecule 1 (VCAM-1) upregulated on inflamed arterial endothelium. Diets high in polyunsaturated fatty acids (PUFAs) may provide athero-protection by ameliorating this effect.<h4>Objective</h4>We investigated the acute regulation of VCAM-1 expression in human aortic ...[more]