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A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus.

ABSTRACT: The use of plants as natural medicines in the treatment of type II diabetes mellitus (T2DM) has long been of special interest. In this work, we developed a docking score-weighted prediction model based on drug-target network to evaluate the efficacy of medicinal plants for T2DM. High throughput virtual screening from chemical library of natural products was adopted to calculate the binding affinity between natural products contained in medicinal plants and 33 T2DM-related proteins. The drug-target network was constructed according to the strength of the binding affinity if the molecular docking score satisfied the threshold. By linking the medicinal plant with T2DM through drug-target network, the model can predict the efficacy of natural products and medicinal plant for T2DM. Eighteen thousand nine hundred ninety-nine natural products and 1669 medicinal plants were predicted to be potentially bioactive.

SUBMITTER: Gu J

PROVIDER: S-EPMC3810496 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus.

Gu Jiangyong J Chen Lirong L Yuan Gu G Xu Xiaojie X

Evidence-based complementary and alternative medicine : eCAM 20131010

The use of plants as natural medicines in the treatment of type II diabetes mellitus (T2DM) has long been of special interest. In this work, we developed a docking score-weighted prediction model based on drug-target network to evaluate the efficacy of medicinal plants for T2DM. High throughput virtual screening from chemical library of natural products was adopted to calculate the binding affinity between natural products contained in medicinal plants and 33 T2DM-related proteins. The drug-targ ...[more]

PMID: 24223610

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Project description:Diabetes and hypertension have been declared as a global health menace of the 21st Century. Thus, the search for potential therapeutic agents from medicinal plants for the management of diabetes and hypertension is important. This study was undertaken to investigate medicinal plants being used in the management of diabetes and hypertension by herbalists in Ghana. Data were obtained from 36 herbalists through questionnaire interviews and conversations. Botanical specimens were collected, processed and identified following standard ethnobotanical methods. Data were analyzed using Fidelity Level (FL) and Informant Consensus Factor (ICF). A total of 39 species of plants belonging to 31 families were reported being used for management of diabetes and hypertension. Eighteen of these plants are used for the treatment of hypertension, 12 species for diabetes, and 9 species for management of both diseases. Informant consensus factor was highest for plants used to treat both diseases (IFC = 0.82) followed by hypertension (ICF = 0.31) and then diabetes (IFC = 0.24). FL values were high for Carica papaya L. Moringa oleifera Lam. and Khaya senegalensis A. Juss. for the management of both diabetes and hypertension. Of the 14 species used for hypertension, Tetrapleura tetraptera (Schum. ex. Thonn.) recorded the highest FL value whiles Momordica charantia L. recorded the highest FL value for antidiabetic plants. Baphia nitida G. Lodd, Luffa aegyptiaca Mill. and Tapinanthus banguwensis (Engl. & k. Krause) Dancing are being mentioned for the first time in the management of hypertension. Herbal medicines for treatments of both diabetes and hypertension were usually prepared from multiple plant prescriptions by boiling the plant parts, and the decoctions drunk for treatments. The results show that there is substantial preclinical evidence to support the usefulness of some of these herbs as an important choice for patients with diabetes and hypertension. However, clinical studies are important to confirm the efficacy and safety of the herbal medicines prescribed by herbalists.

Project description:Background: Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and compare the efficacy of different pharmacist based interventions on clinical outcomes of type 2 diabetes patients. Methods: A systematic search was conducted across five databases from date of database inception to September 2017. All randomized clinical trials evaluating the efficacy of pharmacist based interventions on type 2 diabetes patients were included for network meta-analysis (NMA). The protocol is available with PROSPERO (CRD42017078854). Results: A total of 43 studies, involving 6259 type 2 diabetes patients, were included. NMA demonstrated that all interventions significantly lowered glycosylated hemoglobin (HbA1c) levels compared to usual care, but there was no statistical evidence from this study that one intervention was significantly better than the other for reducing HbA1c levels. Pharmacist based diabetes education plus pharmaceutical care showed maximum efficacy for reducing HbA1c levels [-0.86, 95% CI -0.983, -0.727; p < 0.001]. Pharmacist based diabetes education plus pharmaceutical care was observed to be statistically significant in lowering levels of systolic blood pressure [-4.94; 95%CI -8.65, -1.23] and triglycerides levels [-0.26, 95%CI -0.51, -0.01], as compared to the interventions which involved diabetes education by pharmacist, and for body mass index (BMI) [-0.57; 95%CI -1.25, -0.12] in comparison to diabetes education by health care team involving pharmacist as member. Conclusion: The findings of this review demonstrate that all interventions had a significantly positive effect on HbA1c, but there was no statistical evidence from this study that one intervention was significantly better than the other for achieving glycemic control.Pharmacist based diabetes education plus pharmaceutical care showed maximum efficacy on HbA1c and rest of the clinical outcomes.

Dataset Information

A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus.

Publications

A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus.

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