Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse.
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ABSTRACT:
SUBMITTER: Lilue J
PROVIDER: S-EPMC3810784 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse.
Lilue Jingtao J Müller Urs Benedikt UB Steinfeldt Tobias T Howard Jonathan C JC
eLife 20131029
Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laborato ...[more]
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