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New structure of phage-related islands carrying fusB and a virulence gene in fusidic acid-resistant Staphylococcus epidermidis.

ABSTRACT: Nucleotide sequencing of the fusB-flanking regions in two fusidic acid-resistant Staphylococcus epidermidis isolates with the type IV aj1-leader peptide (LP)-fusB structure (lacking aj1) revealed that their fusB gene was located on novel phage-related islands inserted downstream of smpB and are here referred to as SeRIfusB-3692 and SePIfusB-857. The novel SePIfusB-857 structure was followed by SeCI857, forming a composite pathogenicity island which contained a putative virulence gene, vapE. The linkage of fusB and vapE may contribute to bacterial adaption.

SUBMITTER: Chen HJ

PROVIDER: S-EPMC3811319 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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New structure of phage-related islands carrying fusB and a virulence gene in fusidic acid-resistant Staphylococcus epidermidis.

Chen Hsiao-Jan HJ Chang Ya-Chun YC Tsai Jui-Chang JC Hung Wei-Chun WC Lin Yu-Tzu YT You Shang-Jie SJ Tseng Sung-Pin SP Teng Lee-Jene LJ

Antimicrobial agents and chemotherapy 20130826 11

Nucleotide sequencing of the fusB-flanking regions in two fusidic acid-resistant Staphylococcus epidermidis isolates with the type IV aj1-leader peptide (LP)-fusB structure (lacking aj1) revealed that their fusB gene was located on novel phage-related islands inserted downstream of smpB and are here referred to as SeRIfusB-3692 and SePIfusB-857. The novel SePIfusB-857 structure was followed by SeCI857, forming a composite pathogenicity island which contained a putative virulence gene, vapE. The ...[more]

PMID: 23979742

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Identification of fusB-mediated fusidic acid resistance islands in Staphylococcus epidermidis isolates.

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The fusidic acid stimulon of Staphylococcus aureus.

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| S-EPMC2583067 | biostudies-literature

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