Ontology highlight
ABSTRACT:
SUBMITTER: Steinchen W
PROVIDER: S-EPMC3811484 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Steinchen Wieland W Lackner Gerald G Yasmin Sabiha S Schrettl Markus M Dahse Hans-Martin HM Haas Hubertus H Hoffmeister Dirk D
Applied and environmental microbiology 20130823 21
The filamentous mold Aspergillus fumigatus causes invasive aspergillosis, a potentially life-threatening infectious disease, in humans. The sidE gene encodes a bimodular peptide synthetase and was shown previously to be strongly upregulated during initiation of murine lung infection. In this study, we characterized the two adenylation domains of SidE with the ATP-[(32)P]pyrophosphate exchange assay in vitro, which identified fumarate and l-alanine, respectively, as the preferred substrates. Usin ...[more]