Ontology highlight
ABSTRACT:
SUBMITTER: Honke N
PROVIDER: S-EPMC3812017 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Honke Nadine N Shaabani Namir N Zhang Dong-Er DE Iliakis George G Xu Haifeng C HC Häussinger Dieter D Recher Mike M Löhning Max M Lang Philipp A PA Lang Karl S KS
PLoS pathogens 20131024 10
Infection with viruses carrying cross-reactive antigens is associated with break of immunological tolerance and induction of autoimmune disease. Dendritic cells play an important role in this process. However, it remains unclear why autoimmune-tolerance is broken during virus infection, but usually not during exposure to non-replicating cross-reactive antigens. Here we show that antigen derived from replicating virus but not from non-replicating sources undergoes a multiplication process in dend ...[more]