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Pulse wave velocity is associated with ?-amyloid deposition in the brains of very elderly adults.

ABSTRACT: To determine arterial stiffness and ?-amyloid (A?) deposition in the brain of dementia-free older adults.We studied a cohort of 91 dementia-free participants aged 83-96 years. In 2009, participants completed brain MRI and PET imaging using Pittsburgh compound B (PiB; a marker of amyloid plaques in human brain). In 2011, we measured resting blood pressure (BP), mean arterial pressure (MAP), and arterial stiffness by pulse wave velocity (PWV) in the central, peripheral, and mixed (e.g., brachial ankle PWV [baPWV]) vascular beds, using a noninvasive and automated waveform analyzer.A total of 44/91 subjects were A?-positive on PET scan. A? deposition was associated with mixed PWV, systolic BP, and MAP. One SD increase in baPWV resulted in a 2-fold increase in the odds of being A?-positive (p = 0.007). High white matter hyperintensity (WMH) burden was associated with increased central PWV, systolic BP, and MAP. Compared to A?-negative individuals with low WMH burden, each SD increase in PWV was associated with a 2-fold to 4-fold increase in the odds of being A?-positive and having high WMH.Arterial stiffness was associated with A? plaque deposition in the brain, independent of BP and APOE ?4 allele. The associations differed by type of brain abnormality and vascular bed measured (e.g., WMH with central stiffness and A? deposition and mixed stiffness). Arterial stiffness was highest in individuals with both high A? deposition and WMH, which has been suggested to be a "double hit" contributing to the development of symptomatic dementia.

SUBMITTER: Hughes TM

PROVIDER: S-EPMC3812104 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.

Hughes Timothy M TM Kuller Lewis H LH Barinas-Mitchell Emma J M EJ Mackey Rachel H RH McDade Eric M EM Klunk William E WE Aizenstein Howard J HJ Cohen Ann D AD Snitz Beth E BE Mathis Chester A CA Dekosky Steven T ST Lopez Oscar L OL

Neurology 20131016 19

<h4>Objective</h4>To determine arterial stiffness and β-amyloid (Aβ) deposition in the brain of dementia-free older adults.<h4>Methods</h4>We studied a cohort of 91 dementia-free participants aged 83-96 years. In 2009, participants completed brain MRI and PET imaging using Pittsburgh compound B (PiB; a marker of amyloid plaques in human brain). In 2011, we measured resting blood pressure (BP), mean arterial pressure (MAP), and arterial stiffness by pulse wave velocity (PWV) in the central, perip ...[more]

PMID: 24132374

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Project description:Background and aimsIn healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals.MethodsWe employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT).ResultsThree principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements.ConclusionsIn this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years.

Dataset Information

Pulse wave velocity is associated with ?-amyloid deposition in the brains of very elderly adults.

Publications

Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.

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