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Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates.


ABSTRACT: Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.

SUBMITTER: Aden U 

PROVIDER: S-EPMC3812267 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates.

Adén Ulrika U   Lin Aiping A   Carlo Waldemar W   Leviton Alan A   Murray Jeffrey C JC   Hallman Mikko M   Lifton Richard P RP   Zhang Heping H   Ment Laura R LR  

The Journal of pediatrics 20130726 5


Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies. ...[more]

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