Ontology highlight
ABSTRACT:
SUBMITTER: Madugundu GS
PROVIDER: S-EPMC3812307 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Madugundu Guru S GS Wagner J Richard JR Cadet Jean J Kropachev Konstantin K Yun Byeong Hwa BH Geacintov Nicholas E NE Shafirovich Vladimir V
Chemical research in toxicology 20130611 7
The one-electron oxidation of cellular DNA in cultured human HeLa cells initiated by intense nanosecond 266 nm laser pulse irradiation produces cross-links between guanine and thymine bases (G*-T*), characterized by a covalent bond between C8 guanine (G*) and N3 thymine (T*) atoms. The DNA lesions were quantified by isotope dilution LC-MS/MS methods in the multiple reaction-monitoring mode using isotopically labeled [(15)N, (13)C]-nucleotides as internal standards. Among several known pyrimidine ...[more]