Ontology highlight
ABSTRACT:
SUBMITTER: Shiomitsu K
PROVIDER: S-EPMC3812382 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Shiomitsu K K Sajo E E Rubin C C Sehgal I I
Veterinary and comparative oncology 20130613 1
ENMD-2076 is an aurora kinase inhibitor that also has multi-target tyrosine kinase inhibitor properties. In this study, the mRNA and the protein expression of aurora-A and aurora-B were evaluated in three canine mast cell tumour cell lines. Dose-dependent cytotoxicity was seen in the cells treated, and it affected the cell cycle with cells in the G2/M phase being selectively killed. The cells were also evaluated for radiosensitivity with/without ENMD-2076, and radiosensitization was seen after 3 ...[more]