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Indolo[3,2-a]carbazoles from a deep-water sponge of the genus Asteropus.

ABSTRACT: Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory concentrations of 25 ?g/mL against the fungal pathogen Candida albicans and 50 ?g/mL against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 1 and 2 showed no cytotoxicity against the PANC1 human pancreatic carcinoma and NCI/ADR-RES ovarian adenocarcinoma cell lines at our standard test concentration of 5 ?g/mL.

SUBMITTER: Russell F 

PROVIDER: S-EPMC3812703 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Indolo[3,2-a]carbazoles from a deep-water sponge of the genus Asteropus.

Russell Floyd F   Harmody Dedra D   McCarthy Peter J PJ   Pomponi Shirley A SA   Wright Amy E AE  

Journal of natural products 20130924 10

Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory concentrations of 25 μg/mL against the fungal pathogen Candida albicans and 50 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 1 and 2 showed no cytotoxicity against the PANC1 human pancreatic  ...[more]

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