Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography.
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ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC3812820 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography.
Zheng Xiwei X Yoo Michelle J MJ Hage David S DS
The Analyst 20131101 21
A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin. ...[more]
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