Ontology highlight
ABSTRACT:
SUBMITTER: Wildbaum G
PROVIDER: S-EPMC381283 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20000901 5
This study used naked DNA vaccination to induce breakdown of tolerance to self and thus elicit immunological memory to native, membrane-bound Fas ligand (FasL). Upon induction of experimental autoimmune encephalomyelitis (EAE), this memory was turned on to provide protective immunity. FasL-specific autoantibodies isolated from protected animals differentially downregulated the in vitro production of TNF-alpha, but not IFN-gamma, by cultured T cells. These autoantibodies were highly protective wh ...[more]