Ontology highlight
ABSTRACT:
SUBMITTER: Masuda H
PROVIDER: S-EPMC3813597 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Clinical cancer research : an official journal of the American Association for Cancer Research 20130815 19
<h4>Purpose</h4>The clinical relevancy of the 7-subtype classification of triple-negative breast cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated the clinical relevancy of TNBC heterogeneity by determining pathologic complete response (pCR) rates after neoadjuvant chemotherapy, based on TNBC subtypes.<h4>Experimental design</h4>We revalidated the Lehmann and colleagues experiments using Affymetrix CEL files from public datasets. We applied these methods to 146 patient ...[more]