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Core-shell hydrogel microcapsules for improved islets encapsulation.

ABSTRACT: Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

SUBMITTER: Ma M

PROVIDER: S-EPMC3814167 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Core-shell hydrogel microcapsules for improved islets encapsulation.

Ma Minglin M Chiu Alan A Sahay Gaurav G Doloff Joshua C JC Dholakia Nimit N Thakrar Raj R Cohen Joshua J Vegas Arturo A Chen Delai D Bratlie Kaitlin M KM Dang Tram T York Roger L RL Hollister-Lock Jennifer J Weir Gordon C GC Anderson Daniel G DG

Advanced healthcare materials 20121203 5

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules. ...[more]

PMID: 23208618

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