Unknown

Dataset Information

0

Evaluation of brief screening tools for neurocognitive impairment in HIV/AIDS: a systematic review of the literature.


ABSTRACT:

Objective(s)

To systematically review literature on brief screening tools used to detect and differentiate between normal cognition and neurocognitive impairment and HIV-associated neurocognitive disorders (HANDs) in adult populations of persons with HIV.

Design

A formal systematic review.

Methods

We searched six electronic databases in 2011 and contacted experts to identify relevant studies published through May 2012. We selected empirical studies that focused on evaluating brief screening tools (<20 min) for neurocognitive impairment in persons with HIV. Two reviewers independently reviewed retrieved literature for potential relevance and methodological quality. Meta-analyses were completed on screening tools that had sufficient data.

Results

Fifty-one studies met inclusion criteria; we focused on 31 studies that compared brief screening tools with reference tests. Within these 31 studies, 39 tools were evaluated and 67% used a comprehensive neuropsychological battery as a reference. The majority of these studies evaluated HIV-associated dementia (HAD). Meta-analyses demonstrated that the HIV Dementia Scale (HDS) has poor pooled sensitivity (0.48) and the International HIV Dementia Scale (IHDS) has moderate pooled sensitivity (0.62) in detecting a range of cognitive impairment. Five newer screening tools had relatively good sensitivities (>0.70); however, none of the tools differentiated HAND conditions well enough to suggest broader use. There were significant methodological shortcomings noted in most studies.

Conclusion

HDS and IHDS perform well to screen for HAD but poorly for milder HAND conditions. Further investigation, with improved methodology, is required to understand the utility of newer screening tools for HAND; further tools may need to be developed for milder HAND conditions.

SUBMITTER: Zipursky AR 

PROVIDER: S-EPMC3814629 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Evaluation of brief screening tools for neurocognitive impairment in HIV/AIDS: a systematic review of the literature.

Zipursky Amy R AR   Gogolishvili David D   Rueda Sergio S   Brunetta Jason J   Carvalhal Adriana A   McCombe Jennifer A JA   Gill M John MJ   Rachlis Anita A   Rosenes Ron R   Arbess Gordon G   Marcotte Thomas T   Rourke Sean B SB  

AIDS (London, England) 20130901 15


<h4>Objective(s)</h4>To systematically review literature on brief screening tools used to detect and differentiate between normal cognition and neurocognitive impairment and HIV-associated neurocognitive disorders (HANDs) in adult populations of persons with HIV.<h4>Design</h4>A formal systematic review.<h4>Methods</h4>We searched six electronic databases in 2011 and contacted experts to identify relevant studies published through May 2012. We selected empirical studies that focused on evaluatin  ...[more]

Similar Datasets

| S-EPMC5912296 | biostudies-literature
| S-EPMC9392617 | biostudies-literature
2024-10-30 | GSE269380 | GEO
| S-EPMC9491510 | biostudies-literature
| S-EPMC10894602 | biostudies-literature
| S-EPMC5303132 | biostudies-literature
| S-EPMC4599391 | biostudies-literature
| S-EPMC4893344 | biostudies-literature
| S-EPMC4776086 | biostudies-literature
| S-EPMC6336535 | biostudies-literature