Ontology highlight
ABSTRACT:
SUBMITTER: Zeng L
PROVIDER: S-EPMC3814778 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Zeng Lingfang L Wang Gang G Ummarino Dario D Margariti Andriana A Xu Qihe Q Xiao Qingzhong Q Wang Wen W Zhang Zhongyi Z Yin Xiaoke X Mayr Manuel M Cockerill Gillian G Li Julie Yi-shuan JY Chien Shu S Hu Yanhua Y Xu Qingbo Q
The Journal of biological chemistry 20130917 44
Histone deacetylase 3 (HDAC3) plays a critical role in the maintenance of endothelial integrity and other physiological processes. In this study, we demonstrated that HDAC3 undergoes unconventional splicing during stem cell differentiation. Four different splicing variants have been identified, designated as HD3α, -β, -γ, and -δ, respectively. HD3α was confirmed in stem cell differentiation by specific antibody against the sequences from intron 12. Immunofluorescence staining indicated that the ...[more]