Ontology highlight
ABSTRACT:
SUBMITTER: Ma Z
PROVIDER: S-EPMC3814876 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ma Zhe Z Moore Robert R Xu Xiangxi X Barber Glen N GN
PLoS pathogens 20131031 10
RIG-I-Like Receptors (RLRs) sense cytosolic viral RNA to transiently activate type I IFN production. Here, we report that a type I IFN inducible DExD/H helicase, DDX24, exerts a negative-regulatory effect on RLR function. Expression of DDX24 specifically suppressed RLR activity, while DDX24 loss, which caused embryonic lethality, augmented cytosolic RNA-mediated innate signaling and facilitated RNA virus replication. DDX24 preferentially bound to RNA rather than DNA species and influenced signal ...[more]