Ontology highlight
ABSTRACT:
SUBMITTER: Lachance J
PROVIDER: S-EPMC3815054 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lachance Joseph J Jung Lawrence L True John R JR
G3 (Bethesda, Md.) 20131106 11
Many genes involved in producing complex traits are incompletely penetrant. One such example is vesiculated, an X-linked gene in Drosophila melanogaster that results in wing defects. To examine the genetic architecture of a complex trait (wings containing vesicles), we placed a naturally occurring variant into multiple autosomal backgrounds and quantified penetrance and expressivity at a range of developmental temperatures. We found significant epistasis, genotype-by-environment interactions, an ...[more]