Modeling the dynamics of bivalent histone modifications.
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ABSTRACT:
SUBMITTER: Ku WL
PROVIDER: S-EPMC3815350 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Modeling the dynamics of bivalent histone modifications.
Ku Wai Lim WL Girvan Michelle M Yuan Guo-Cheng GC Sorrentino Francesco F Ott Edward E
PloS one 20131101 11
Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathemati ...[more]
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