Ontology highlight
ABSTRACT:
SUBMITTER: Burnett-Hartman AN
PROVIDER: S-EPMC3815695 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Burnett-Hartman Andrea N AN Newcomb Polly A PA Potter John D JD Passarelli Michael N MN Phipps Amanda I AI Wurscher Michelle A MA Grady William M WM Zhu Lee-Ching LC Upton Melissa P MP Makar Karen W KW
Cancer research 20130328 9
A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status of these markers in colorectal polyps and evaluated associated risk factors. The study included 771 polyp cases and 1,027 controls who were ages 24 to 80 years, part of a group health program, received a colonoscopy from 1998 to 2007, and completed a structured questionnaire assessing risk f ...[more]