Ontology highlight
ABSTRACT:
SUBMITTER: Harms MB
PROVIDER: S-EPMC3815699 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Neurologic clinics 20131101 4
Our understanding of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is expanding rapidly as its genetic causes are uncovered. The pace of new gene discovery over the last 5 years has accelerated, providing new insights into the pathogenesis of disease and highlighting biological pathways as targets for therapeutic development. This article reviews our current understanding of the heritability of ALS and provides an overview of each of the major ALS genes, highlighting th ...[more]