Dataset Information

Evaluation of slice accelerations using multiband echo planar imaging at 3 T.

ABSTRACT: We evaluate residual aliasing among simultaneously excited and acquired slices in slice accelerated multiband (MB) echo planar imaging (EPI). No in-plane accelerations were used in order to maximize and evaluate achievable slice acceleration factors at 3 T. We propose a novel leakage (L-) factor to quantify the effects of signal leakage between simultaneously acquired slices. With a standard 32-channel receiver coil at 3 T, we demonstrate that slice acceleration factors of up to eight (MB=8) with blipped controlled aliasing in parallel imaging (CAIPI), in the absence of in-plane accelerations, can be used routinely with acceptable image quality and integrity for whole brain imaging. Spectral analyses of single-shot fMRI time series demonstrate that temporal fluctuations due to both neuronal and physiological sources were distinguishable and comparable up to slice-acceleration factors of nine (MB=9). The increased temporal efficiency could be employed to achieve, within a given acquisition period, higher spatial resolution, increased fMRI statistical power, multiple TEs, faster sampling of temporal events in a resting state fMRI time series, increased sampling of q-space in diffusion imaging, or more quiet time during a scan.

SUBMITTER: Xu J

PROVIDER: S-EPMC3815955 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Evaluation of slice accelerations using multiband echo planar imaging at 3 T.

Xu Junqian J Moeller Steen S Auerbach Edward J EJ Strupp John J Smith Stephen M SM Feinberg David A DA Yacoub Essa E Uğurbil Kâmil K

NeuroImage 20130727

We evaluate residual aliasing among simultaneously excited and acquired slices in slice accelerated multiband (MB) echo planar imaging (EPI). No in-plane accelerations were used in order to maximize and evaluate achievable slice acceleration factors at 3 T. We propose a novel leakage (L-) factor to quantify the effects of signal leakage between simultaneously acquired slices. With a standard 32-channel receiver coil at 3 T, we demonstrate that slice acceleration factors of up to eight (MB=8) wit ...[more]

PMID: 23899722

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Project description:BACKGROUND:Subject motion is known to produce spurious covariance among time-series in functional connectivity that has been reported to induce distance-dependent spurious correlations. PURPOSE:To present a feasibility study for applying the extended Kalman filter (EKF) framework for high temporal resolution motion correction of resting state functional MRI (rs-fMRI) series using each simultaneous multi-slice (SMS) echo planar imaging (EPI) shot as its own navigator. STUDY TYPE:Prospective feasibility study. POPULATION/SUBJECTS:Three human volunteers. FIELD STRENGTH/SEQUENCE:3T GE DISCOVERY MR750 scanner using a 32-channel head coil. Simultaneous multi-slice rs-fMRI sequence with repetition time (TR)/echo time (TE) = 800/30 ms, and SMS factor 6. ASSESSMENT:Motion estimates were computed using two techniques: a conventional rigid-body volume-wise registration; and a high-temporal resolution motion estimation rigid-body approach. The reference image was resampled using the estimates obtained from both approaches and the difference between these predicted volumes and the original moving series was summarized using the normalized mean squared error (NMSE). STATISTICAL TESTS:Direct comparison of NMSE values. RESULTS:High-temporal motion estimation was always superior to volume-wise motion estimation for the sample presented. For staged continuous rotations, the NMSE using high-temporal resolution motion estimates ranged between [0.130, 0.150] for the first volunteer (in-plane rotations), between [0.060, 0.068] for the second volunteer (in-plane rotations), and between [0.063, 0.080] for the third volunteer (through-plane rotations). These values went up to [0.384, 0.464]; [0.136, 0.179]; and [0.080, 0.096], respectively, when using volume-wise motion estimates. DATA CONCLUSION:Accurate high-temporal rigid-body motion estimates can be obtained for rs-fMRI taking advantage of simultaneous multi-slice EPI sub-TR shots. LEVEL OF EVIDENCE:2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018.

Project description:PurposeSpin-echo functional MRI (SE-fMRI) has the potential to improve spatial specificity when compared with gradient-echo fMRI. However, high spatiotemporal resolution SE-fMRI with large slice-coverage is challenging as SE-fMRI requires a long echo time to generate blood oxygenation level-dependent (BOLD) contrast, leading to long repetition times. The aim of this work is to develop an acquisition method that enhances the slice-coverage of SE-fMRI at high spatiotemporal resolution.Theory and methodsAn acquisition scheme was developed entitled multisection excitation by simultaneous spin-echo interleaving (MESSI) with complex-encoded generalized slice dithered enhanced resolution (cgSlider). MESSI uses the dead-time during the long echo time by interleaving the excitation and readout of 2 slices to enable 2× slice-acceleration, while cgSlider uses the stable temporal background phase in SE-fMRI to encode/decode 2 adjacent slices simultaneously with a "phase-constrained" reconstruction method. The proposed cgSlider-MESSI was also combined with simultaneous multislice (SMS) to achieve further slice-acceleration. This combined approach was used to achieve 1.5-mm isotropic whole-brain SE-fMRI with a temporal resolution of 1.5 s and was evaluated using sensory stimulation and breath-hold tasks at 3T.ResultsCompared with conventional SE-SMS, cgSlider-MESSI-SMS provides 4-fold increase in slice-coverage for the same repetition time, with comparable temporal signal-to-noise ratio. Corresponding fMRI activation from cgSlider-MESSI-SMS for both fMRI tasks were consistent with those from conventional SE-SMS. Overall, cgSlider-MESSI-SMS achieved a 32× encoding-acceleration by combining Rinplane × MB × cgSlider × MESSI = 4 × 2 × 2 × 2.ConclusionHigh-quality, high-resolution whole-brain SE-fMRI was acquired at a short repetition time using cgSlider-MESSI-SMS. This method should be beneficial for high spatiotemporal resolution SE-fMRI studies requiring whole-brain coverage.

Dataset Information

Evaluation of slice accelerations using multiband echo planar imaging at 3 T.

Publications

Evaluation of slice accelerations using multiband echo planar imaging at 3 T.

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