Local connection patterns of parvalbumin-positive inhibitory interneurons in rat primary auditory cortex.

ABSTRACT: In the auditory cortex (AC), GABAergic neurons constitute approximately 15-25% of all neurons. GABAergic cells are present in all sensory modalities and essential for modulating sensory receptive fields. Parvalbumin (PV) positive cells represent the largest sub-group of the GABAergic population in auditory neocortex. We investigated the projection pattern of PV cells in rat primary auditory cortex (AI) with a retrograde tracer (wheat germ apo-HRP conjugated to gold [WAHG]) and immunocytochemistry for PV. All AC layers except layer I contained cells double-labeled for PV and WAHG. All co-localized PV+ cells were within 2 mm of the injection site, regardless of laminar origin. Most (ca. 90%) of the co-localized PV cells were within 500 μm of the injection site in both dorsal-ventral and rost

SUBMITTER: Yuan K 

PROVIDER: S-EPMC3816087 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature