Ontology highlight
ABSTRACT:
SUBMITTER: Klos Dehring DA
PROVIDER: S-EPMC3816757 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Klos Dehring Deborah A DA Vladar Eszter K EK Werner Michael E ME Mitchell Jennifer W JW Hwang Peter P Mitchell Brian J BJ
Developmental cell 20130926 1
The ability of cells to faithfully duplicate their two centrioles once per cell cycle is critical for proper mitotic progression and chromosome segregation. Multiciliated cells represent an interesting variation of centriole duplication in that these cells generate greater than 100 centrioles, which form the basal bodies of their motile cilia. This centriole amplification is proposed to require a structure termed the deuterosome, thought to be capable of promoting de novo centriole biogenesis. H ...[more]