Dataset Information

Genetic variability of inflammatory genes in the Brazilian population.

ABSTRACT: Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, I?BL -62AT, I?BL -262CT, tumor necrosis factors alpha (TNFa) -238GA, TNFa -308GA, lymphotoxin-alpha (LTa) +80AC, LTa +252AG, FAS -670AG, and FASL -844TC, considering the white, black, and Pardo ethnicities of the São Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy-Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population.

SUBMITTER: dos Santos M

PROVIDER: S-EPMC3816776 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Genetic variability of inflammatory genes in the Brazilian population.

dos Santos Marcelo M Stur Elaine E Maia Lucas Lima LL Agostini Lidiane Pignaton LP Peterle Gabriela Tonini GT Mendes Suzanny Oliveira SO Tajara Eloiza Helena EH de Carvalho Marcos Brasilino MB Louro Iúri Drumond ID Silva-Conforti Adriana Madeira Álvares AM

Genetic testing and molecular biomarkers 20130803 11

Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the B ...[more]

PMID: 23909556

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Dataset Information

Genetic variability of inflammatory genes in the Brazilian population.

Publications

Genetic variability of inflammatory genes in the Brazilian population.

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