Dataset Information
Association between TGF-?1 polymorphisms and hepatocellular carcinoma risk: a meta-analysis.
Ontology highlight
ABSTRACT: Background
Associations between transforming growth factor (TGF)-?1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations.Methods
We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.Results
A total of 14 studies were included in this meta-analysis. TGF-?1 +869C/T polymorphism was significantly associated with HCC risk (OR=1.74, 95% CI: 1.22-2.47, p=0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR=1.40, 95% CI: 1.15-1.70, p=0.0007). Furthermore, significant associations between these polymorphisms and HCC risk were found in Asians and population-based studies.Conclusions
Our meta-analysis suggested that the TGF-?1 +869C/T and -509C/T polymorphisms may be risk factors for developing HCC.
SUBMITTER: Guo Y
PROVIDER: S-EPMC3816781 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Association between TGF-β1 polymorphisms and hepatocellular carcinoma risk: a meta-analysis.
Genetic testing and molecular biomarkers 20130909 11
<h4>Background</h4>Associations between transforming growth factor (TGF)-β1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations.<h4>Methods</h4>We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.<h4>Results</h4>A ...[more]